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natural product library  (TargetMol)


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    TargetMol natural product library
    Natural Product Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 95/100, based on 98 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/natural product library/product/TargetMol
    Average 95 stars, based on 98 article reviews
    natural product library - by Bioz Stars, 2026-05
    95/100 stars

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    Agrimol B inhibits PDAC growth both in vitro and in vivo . (A) A CCK-8 assay was used to evaluate the pharmacodynamic patterns of 62 natural polyphenols. (B) Polyphenol classification and chemical structure. (C) Viability of PANC-1 cells treated with 62 drugs (10 μmol/l). (D) Chemical structure of Agrimol B. (E) PANC-1, CFPAC-1, and AsPC-1 cell lines were treated with various concentrations of Agrimol B for 24 h. (F) IC50 of Agrimol B in PDAC cells. (G, H) PDAC cells were treated with the indicated concentrations of Agrimol B. Cell proliferation was measured by a colony formation assay. (I) Flow cytometric analysis of PDAC cells treated with different concentrations of Agrimol B for 24 h. (J) Western blot analysis of caspase 9 and cleaved caspase 9 in PDAC cells treated with the indicated concentrations of Agrimol B for 24 h. (K) Tumours from the xenograft model treated with Agrimol B or vehicle. (M, N) Tumour volume and weight in mice in the cohorts treated with Agrimol B or vehicle. (L, O) Immunohistochemical staining of Ki67 in a xenograft model from the vehicle group or the Agrimol B group. Relative immunohistochemical scores were determined by multiplying the range of positively stained cells. Scale bars, 100 μm.

    Journal: Precision Clinical Medicine

    Article Title: Agrimol B inhibits pancreatic ductal adenocarcinoma by induction of lethal mitophagy through decreasing mitochondrial transcription termination factor 3

    doi: 10.1093/pcmedi/pbag009

    Figure Lengend Snippet: Agrimol B inhibits PDAC growth both in vitro and in vivo . (A) A CCK-8 assay was used to evaluate the pharmacodynamic patterns of 62 natural polyphenols. (B) Polyphenol classification and chemical structure. (C) Viability of PANC-1 cells treated with 62 drugs (10 μmol/l). (D) Chemical structure of Agrimol B. (E) PANC-1, CFPAC-1, and AsPC-1 cell lines were treated with various concentrations of Agrimol B for 24 h. (F) IC50 of Agrimol B in PDAC cells. (G, H) PDAC cells were treated with the indicated concentrations of Agrimol B. Cell proliferation was measured by a colony formation assay. (I) Flow cytometric analysis of PDAC cells treated with different concentrations of Agrimol B for 24 h. (J) Western blot analysis of caspase 9 and cleaved caspase 9 in PDAC cells treated with the indicated concentrations of Agrimol B for 24 h. (K) Tumours from the xenograft model treated with Agrimol B or vehicle. (M, N) Tumour volume and weight in mice in the cohorts treated with Agrimol B or vehicle. (L, O) Immunohistochemical staining of Ki67 in a xenograft model from the vehicle group or the Agrimol B group. Relative immunohistochemical scores were determined by multiplying the range of positively stained cells. Scale bars, 100 μm.

    Article Snippet: The polyphenol natural product library (L6100) and Agrimol B (T4S1173) were purchased from TargetMol.

    Techniques: In Vitro, In Vivo, CCK-8 Assay, Colony Assay, Western Blot, Immunohistochemical staining, Staining